Abstract #1697

Characterization of Brain Tumors using Amide Proton and Nuclear Overhauser Effect at 3 Tesla MR Scanner.

Yuki Kanazawa¹, Masafumi Harada¹, Mitsuharu Miyoshi², Takashi Abe¹, Yuki Matsumoto¹, and Yasushi Takagi³

¹Tokushima University, Tokushima, Japan, ²Global MR Applications and Workflow, GE Healthcare Japan, Hino, Japan, ³Department of Neurosurgery, Tokushima University, Tokushima, Japan

To achieve detailed characterization of brain tumors, we demonstrated CEST imaging with multi-pool model [bulk water, magnetization transfer (MT), amide proton transfer (APT), and nuclear Overhauser effect (NOE)] derive from the Bloch equation. This study was performed using five patients with brain tumors. As a result, there was high linearity between MTR_asym and T₂/T₁ in each tumor (R² = 0.91, P<0.05). Moreover, there were significantly different NOE signals for tumors and normal white matter (P<0.05). Detection using APT and NOE make it possible to provide more detailed information of brain tumors than MTR_asym analysis.

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