Conventional imaging is insufficient for diagnosis and management of patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Brachial and lumbosacral plexus of 37 CIDP patients and 37 age and gender-matched controls were examined by using multi-sequences. Our study showed that fractional anisotropy (FA) had the most sensitivity, while contrast-enhanced ratio (CR) had the most specificity in single-parameter. The combination of FA and CR value had the best diagnostic efficiency. FA had a negative correlation with course duration, and CR positive correlation with CSF protein. SPACE combined with DTI and contrast enhancement sequences serve as a recommended composite protocol.