Abstract #1941

MRI assessment of vascular disruption in tau pathology animal model (rTg4510 mouse) of Alzheimer disease

Kwangyeol Baek¹, Rachel Bennett², Bradley Hyman², Woo Hyun Shim³, and Young Ro Kim^4,5

¹School of Biomedical Convergence Engineering, Pusan National University, Busan, Republic of Korea, ²Department of Neurology, Massachusetts General Hospital and Harvard Medical School,, Boston, MA, United States, ³Department of Radiology, Asan Medical Center, Seoul, Korea, Republic of, ⁴Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁵Department of Radiology, Harvard Medical School, Boston, MA, United States

We assessed vascular disruption in rTg4510 mouse (age of 6 and 9 months), a tau expressing transgenic animal model of Alzheimer’s disease, using MRI metrics such as vessel size index (VSI), Gd-DTPA leakge through BBB and water exchange index (WEI). The rTg4510 mice showed age-dependent expansion of the hippocampal lesion and profound vascular alteration around the hippocampal lesion: Increase in VSI, mild Gd-DTPA leakage and increased WEI. Our findings suggest the role of vascular components in development of Alzheimer’s disease with tau pathology. Vascular MRI assessments might have a potential application in early diagnosis and monitoring of Alzheimer’s disease.

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