Abstract #1961

Disrupted integration of single-subject gray matter networks in suicidality of MDD

Huiru Li¹, Jing Yang¹, Huawei Zhang¹, Li Yin², Qiyong Gong^1,3, and Zhiyun Jia^1,4

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, ²Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China, ³Psychoradiology Research Unit of Chinese Academy of Medical Sciences (2018RU011), Chengdu, China, ⁴Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China, Chengdu, China

In this study, we explore suicidal brain of depression from the level of network connection to capture the complex connectivity alterations of gray matter networks that support higher cognitive and affective processes. We constructed single-subject morphological brain gray matter networks and small-world parameters (C_p, L_p, γ, λ and σ), network efficiency parameters (E_loc and E_glob) and nodal properties (nodal degree, efficiency and centrality). We found decreased σ/E_glob and increased L_p/λ in SU compared to PC and HC. In summary, suicidality involves complex neocortical network organization and showed a weaker integration compared PC and HC.

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