Widespread progressive cortical thinning is a long-standing finding in Psychotic Spectrum Disorders (PSD). While previous histological studies have documented an array of microstructural deficits in the thinning cortex in PSD few techniques have been available to examine these microstructural changes in vivo. We employed the diffusion kurtosis imaging (DKI) technique alongside the classical T1-weighted measure of cortical thickness to describe microstructural changes in the PSD cortex over the first 10 years of the illness. We found, for the first time, that DKI metrics of tissue complexity were significantly positively related to PSD illness progression in the cortex.
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