Analysis of resting-state networks alterations of first-episode obsessive–compulsive disorder patients by independent component analysis

So far, there is no consensus on the cause of obsessive-compulsive disorder（OCD）. We used a data-driven method, independent component analysis (ICA), to study the change of whole brain resting-state functional connectivity of first-episode and treatment-naïve patients with OCD. Three abnormal resting-state networks, posterior default-mode network, right frontoparietal network and lateral visual network, have been found in patients. In addition, patients showed increased functional connection in bilateral cuneus, right inferior parietal lobule and right middle occipital lobule compared with controls. It’s considered that changes of abnormal resting-state networks might reveal the possible neural mechanism of OCD.