Deep brain stimulation (DBS) in the subthalamic nucleus (STN) is an effective therapy for the motor signs associated with Parkinson’s disease. The STN is organized into three main functional territories, motor, associative and limbic, that can be identified using structural connectivity-based parcellation. While many may argue that the DBS electrode should be implanted in the sensorimotor region for maximum motor benefits, the optimal location within the STN remains under debate. In this study we describe a patient who experienced STN-DBS-induced depression, which was significantly alleviated following revision of the electrode. A 7T imaging-based reconstruction provides an explanation for this observation.
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