Abstract #2055

Reproducibility of diffusion tensor imaging (DTI) on 12 clinical scanners: Towards validation of cardiac DTI sequences.

Irvin Teh¹, William Romero², Erica Dall'Armellina¹, Daniel Ennis³, Pedro F. Ferreira⁴, Prateek Kalra⁵, Arunark Kolipaka⁵, Sebastian Kozerke⁶, David Lohr⁷, Kevin Moulin⁸, Christopher Nguyen⁹, Sonia Nielles-Vallespin⁴, Beau Pontre¹⁰, Laura M. Schreiber⁷, Andrew Scott⁴, David Sosnovik⁹, Christian T. Stoeck⁶, Cyril Tous¹¹, Elizabeth Tunnicliffe¹², Vicky Wang¹³, Andreas M. Weng¹⁴, Alistair Young¹⁵, Pierre Croisille², Magalie Viallon², and Jürgen E. Schneider¹

¹Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, ²Université de Lyon, UJM-Saint-Etienne, INSA, CNRS UMR 5520, INSERM U1206, CREATIS, F-42023, Saint Etienne, France, ³Department of Radiology, VA Palo Alto Health Care System, Palo Alto, CA, United States, ⁴Royal Brompton Hospital and Imperial College, London, United Kingdom, ⁵Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ⁶Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, ⁷Department of Cardiovascular Imaging, Comprehensive Heart Failure Center, Würzburg, Germany, ⁸Stanford University, Stanford, CA, United States, ⁹Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, ¹⁰Department of Anatomy and Medical Imaging, The University of Auckland, Auckland, New Zealand, ¹¹Department of Radiology, Radiation-Oncology and Nuclear Medicine and Institute of Biomedical Engineering, Université de Montréal, Montréal, QC, Canada, ¹²University of Oxford, Oxford, United Kingdom, ¹³San Francisco Veteran Affairs Medical Center, San Francisco, CA, United States, ¹⁴Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, ¹⁵Department of Biomedical Engineering, King's College London, London, United Kingdom

Cardiac diffusion tensor imaging (DTI) is increasingly used for non-invasive in vivo characterisation of cardiac microstructure. To help reconcile the variation in DTI metrics in the literature, we investigated the inter- and intra-site variation of DTI across twelve clinical scanners. Data were acquired at two time points, with a standardised isotropic phantom, acquisition, and post-processing pipeline. In water at 0°C, the coefficient of variation of mean diffusivity (MD) across sites was 1.9 ± 1.4% (mean ± SD), while the mean difference across two scans was (-0.010 ± 0.098) × 10^-3mm²/s (mean ± 1.96SD), indicating low bias and good reproducibility.

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