Simultaneous 18F-FDG PET-MR imaging has shown promise for improved diagnostic accuracy of inflammatory cardiac diseases, such as cardiac sarcoidosis. However, respiratory motion and mis-registration between free-breathing 3D PET and conventional 2D breath-held MR images remain a challenge that has hindered clinical adoption of this technique. Here we introduce a 3x-accelerated free-breathing motion-corrected 3D whole-heart T2-mapping prototype sequence, which provides characterisation of myocardial inflammation while additionally providing non-rigid respiratory deformation fields to correct simultaneously acquired PET data. Results from phantom, healthy subjects and patients show that the method produces good-quality high-resolution 3D T2 maps from an efficient scan of ~10 minutes.
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