Preliminary findings are presented from a prospective, longitudinal hyperpolarised 129Xe MRI study of idiopathic pulmonary fibrosis patients. To date, 28 patients have undergone baseline 129Xe DW-MRI and 10 patients have returned for a six-month scan. 14 patients have undergone baseline dissolved 129Xe imaging using IDEAL CSI method. Regional values were produced by separating the lung into three zones. We demonstrate regional differences in 129Xe gas transfer and 129Xe DW-MRI measurements. LmD was found to be more sensitive to longitudinal change than ADC. Over a six-month period, the significant change in mean 129Xe LmD was observed in the lower zone only.