Axially reformatted (AR) SMS can provide full-coverage breast DWI with high quality and 1.25 mm isotropic nominal resolution. In this work we assess the image quality of AR-SMS in a clinical setting and compare it with a standard clinical sequence and RS-EPI. Three radiologists scored DWI and ADC maps from 30 patients with enhancing lesions. All three readers scored AR-SMS with the highest quality and ranked it as superior most frequently. Accounting for reader and subject effects, a linear mixed model found that AR-SMS outperformed RS-EPI, which both outperformed the Standard with statistical significance in both quality score and rank.