Abstract #2572

Longitudinal Study of T2*-based BOLD Placental MRI in Obese Pregnant Human Subjects

Ante Zhu^1,2, Jitka Starekova², Tom Batan³, Kevin Johnson^2,4, Scott B. Reeder^1,2,4,5,6, Oliver Wieben^1,2,4, Dinesh Shah⁷, and Diego Hernando^1,2,4,8

¹Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Integrative Biology, University of Wisconsin-Madison, Madison, WI, United States, ⁴Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁵Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁶Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁷Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, United States, ⁸Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, United States

Maternal obesity is associated with increased risk of gestational hypertension, preeclampsia and fetal growth restriction, complications related to reduced uteroplacental blood flow and placental vascularity malformation. T₂^* measurements of blood oxygen level-dependent effects have promise for assessing placental function. Here, we measured placental T₂^* in non-obese and obese pregnant women at 14 and 20 weeks of gestation. Our study showed that the range of placental T₂^* is similar between the two populations at both gestation ages. Trends of decreased and increased placental T₂^*with gestation were observed in different subjects, suggesting longitudinal changes in placental T₂^* may vary among subjects.

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