Previous studies have reported preliminary but promising results that high b‐value DWI has a remarkably high sensitivity in neuro or genitourinary malignancies. However, the value of high b-value DWI in liver remains controversial. In the current study, multiple high b-values DWI - based texture analysis was applied to evaluate tumor heterogeneity in hepatocellular carcinoma (HCC) patients. The results demonstrated that ultra-high b-value (b = 2000 and 3000 s/mm2) DWI images could offer more information in tumor heterogeneity evaluation compared to the conventional b-value (b = 800 s/mm2) DWI images based on texture analysis in HCC patients.
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