Abstract #2694

Dynamic Contrast Enhanced MR Imaging of Synovitis: Repeatability, Discriminative Validity and Responsiveness in Knee Osteoarthritis

James MacKay^1,2, Faezeh Sanaei Nehad³, Josh Kaggie², Jo Naish³, Caleb Roberts³, Martin Graves², Fiona Gilbert², Andrew McCaskie⁴, John Waterton^3,5, Rob Janiczek⁶, Alexandra Roberts⁶, and Geoff Parker³

¹Radiology, University of East Anglia, Norwich, United Kingdom, ²Radiology, University of Cambridge, Cambridge, United Kingdom, ³BiOxyDyn Ltd, Manchester, United Kingdom, ⁴Surgery, University of Cambridge, Cambridge, United Kingdom, ⁵Informatics, Imaging & Data Sciences, University of Manchester, Manchester, United Kingdom, ⁶Clinical Imaging, GlaxoSmithKline, Stevenage, United Kingdom

Synovitis is common in knee osteoarthritis (OA) and can be quantified using dynamic contrast-enhanced MR imaging (DCE-MRI). There is a strong rationale for therapeutic targeting of synovitis in OA, and imaging biomarkers derived from DCE-MRI may help evaluate response in clinical trials.

Here we evaluate the test-retest repeatability, ability to discriminate between OA (n = 14) and age-matched controls (n = 6) and 6-month responsiveness to change of three DCE-MRI biomarkers: K^trans, IAUC₆₀, and synovial tissue volume.

K^trans demonstrated the best repeatability, discrimination and sensitivity to change suggesting that it is the optimal DCE-MRI biomarker for use in clinical trials.

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