The benefits of multi-echo single-shot (MESS) spectroscopy are explored aiming at simultaneous determination of metabolite content and T2 times through simultaneous linear-combination model fitting of partially sampled echoes. Cramer-Rao lower bounds (CRLB) and Monte-Carlo simulations are used to judge this benefit. The novel scheme was compared with traditional multi-echo multi-shot and single-echo methods, exploring different TE settings for spectra of the major brain metabolites. Results indicate that MESS outperforms older methods for simultaneous determinations of T2s and concentrations, with improvements ranging at 20-30% for T2s and 30-50% for areas. However, for concentrations alone traditional single-echo sequences are more sensitive.
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