MRS has rarely been applied for postmortem measurements except for single-voxel studies, which can be explained by the fact that rapid degradation of metabolite levels makes scanning of fresh specimen highly critical.SVS contrary to MRSI cannot cover whole affected regions, while pathological changes may not be visible on anatomical images, yet. To investigate changes ex-vivo, a true whole-brain MRSI approach is critical. Our study shows the potential of ultra-highfield whole-brain FID-MRSI for metabolic fingerprinting of fresh postmortem brains for correlation with histology, as the link between neurochemical changes and underlying cell-types in many demyelinating/neurodegenerative disorders is still not fully understood.
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