Beta-Hydroxybutyrate (BHB) is a marker of metabolic ketosis in brain. To study ketogenic treatment spectral editing was developed to invert the signals in the 3.2-4.6 ppm spectral region for detecting BHB and co-edited signals. Using this spectral editing technique we found markedly elevated BHB signal in the human brain shortly after oral administration of 1,3-butanediol monoester of beta-hydroxybutyrate as compared to the control scan without consumption of the ketone ester.
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