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Abstract #2949

MR Spectroscopic Differences of Low and High Grade TERTp-only Gliomas

Banu Sacli-Bilmez1, Ayhan Gursan2, Ayca Ersen Danyeli3, Cengiz Yakicier4, M.Necmettin Pamir5,6, Koray Ozduman5,6, Alp Dincer5,7, and Esin Ozturk-Isik1
1Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, 2Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 3Department of Medical Pathology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 4Department of Molecular Biology and Genetics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 5Center for Neuroradiological Applications and Reseach, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 6Department of Neurosurgery, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 7Department of Radiology, Ac─▒badem Mehmet Ali Aydinlar University, Istanbul, Turkey

Gliomas that only have the telomerase reverse transcriptase promoter mutation (TERTp-only) are known to have the worst overall survival. The aim of this study was to analyze magnetic resonance spectroscopic (MRS) differences of different grades of TERTp-only gliomas, and classify these groups using machine learning. The results indicated that the ratios of glycerophosphocholine (GPC), glutathione (GSH), total choline (tCho), and glutamine and glutamate complex (Glx) to total creatine increased along with the tumor grade, and machine learning models classified low- and high-grade TERTp-only gliomas with a high accuracy.

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