The aim of this study was to investigate morphological and metabolic changes in the brain of model mice with AD by using combined 1H-31P MRS and 3D T2 MRI in an integrated way. To investigate the AD-related metabolic changes, mean concentrations and /PCr relative ratios were compared between the groups for all major metabolites. In addition, a volumetric analysis was conducted on the volume of hippocampus, entorhinal cortex, and PFC between the groups. The AD-related changes in brain can be investigated by high-field and short-TE 1H MRS and high-resolution T2-weighted MRI in conjugate with the altas-based automatic brain segmentation.
This abstract and the presentation materials are available to members only; a login is required.