Patients with the adipose disorder lipedema exhibit elevated sodium in the extremities, potentially due to blood or lymphatic vasculopathy. Despite evidence of psychological symptoms, these parameters have not been examined in the brain. We utilized multi-nuclear imaging (23Na-MRI) and arterial spin labeling to test whether dysregulation of brain sodium and perfusion is present in women with (n=15) versus without (n=18) lipedema. We observed lower brain sodium (61.3±6.9 vs. 67.9±5.8mmol/L; p=0.03) and higher cerebral blood flow (43.3±7.0 vs. 37.9±6.3ml blood/100mg tissue/min; p=0.03) in lipedema compared to control participants. Results suggest that brain sodium and hemodynamic dysregulation may exist in lipedema patients.