Abstract #2996

19F MRS Detection of Tau Aggregates Using Lansoprazole in an Ex Vivo Rat Model of Alzheimer’s Disease

Sarah K Yeo¹, Yurii Shepelytskyi², Vira Grynko², Francis T Hane^3,4, Tao Li³, and Mitchell S Albert^3,4,5

¹Biology, Lakehead University, Thunder Bay, ON, Canada, ²Chemistry and Materials Science, Lakehead University, Thunder Bay, ON, Canada, ³Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, ⁴Chemistry, Lakehead University, Thunder Bay, ON, Canada, ⁵Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein are pathological characteristics of Alzheimer’s Disease (AD). Thus, the use of biosensors that bind to NFTs are beneficial for in vivo detection of tauopathy. This study evaluates the use of Lansoprazole (LSZ) as an indicator of NFTs in AD brains. ¹⁹F MRS of AD and control brains with LSZ was acquired using a 3.0T clinical MRI scanner. We demonstrate that the ¹⁹F signal from LSZ interacts with NFTs in a rat model of AD. This shows potential in using LSZ to distinguish between AD and healthy brains with a clinical 3.0T scanner.

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