Here, we demonstrate multi-compartment in vivo pH imaging in healthy and EL4-tumor bearing mice using deuterated hyperpolarized [1,5‑13C2, 3,6,6,6-D4]zymonic acid. Three pH-compartments of the healthy kidney (pHureter = 6.53±0.16, pHmedulla = 7.06±0.06 and pHcortex = 7.38±0.03) could be reliably detected using PRESS-voxel spectroscopy and chemical shift imaging. pH-imaging in mice bearing subcutaneous EL4-tumors allowed to identify one physiologic (pHphys = 7.39±0.05) and two acidic pH-compartments in the tumour (pHac,1 = 6.96±0.17, n=5), with the second pH-compartment being only present in subregions (pHac,2 = 6.62±0.10, n=5).
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