Abstract #3027

Fast 3D hyperpolarized 13C metabolic MRI at 7 T using spectrally selective bSSFP

Jason Graham Skinner¹, Geoffrey Topping¹, Irina Heid², Maximilian Aigner¹, Martin Grashei¹, Christian Hundshammer¹, Lukas Kritzner², Frits Hendrik Anton van Heijster¹, Tim Wartewig^3,4, Erik Hameister^3,4, Jürgen Ruland^3,4,5,6, Rickmer Braren², and Franz Schilling¹

¹Nuclear Medicine, Klinikum rechts der Isar, The Technical University of Munich, Munich, Germany, ²Institute of Radiology, Klinikum rechts der Isar, The Technical University of Munich, Munich, Germany, ³Institute for Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, The Technical University of Munich, Munich, Germany, ⁴TranslaTUM, Center for Translational Cancer Research, The Technical University of Munich, Munich, Germany, ⁵German Cancer Consortium (DKTK), Heidelberg, Germany, ⁶German Center for Infection Research (DZIF), Munich, Germany

A fast, spectrally selective 3D bSSFP sequence was developed for preclinical metabolic imaging of hyperpolarized ¹³C agents at 7 T. High spatiotemporal resolution 3D images of metabolism were produced in healthy mice and in two endogenous models of cancer: pancreatic ductal adenocarcinoma (PDAC) and T-cell lymphoma. Using 900 Hz FHWM pulses, 1.75 mm³ isotropic whole-body images were obtained with a scantime of 1.212 s per image. A significant difference between 3D bSSFP derived AUC ratios in healthy and high-glycolytic-phenotype T-cell lymphoma mice was found, and AUC ratios correlated with PET measurements. Potential tumour heterogeneity was detected in PDAC mice.

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