Magnetic resonance spectroscopic imaging of hyperpolarized [2-13C] Pyruvate and its metabolic products enables real-time assessment of in vivo glycolysis and oxidative phosphorylation simultaneously. However, significant technical difficulties arising from the widely dispersed spectrum and the J-coupling of the 13C labeled carbon with its chemically bonded proton limit its practical use for imaging. We propose a narrowband radiofrequency excitation based-method for eliminating the J-modulated artifacts in imaging [2-13C] Lactate. Results from simulations, phantoms and rat brain demonstrate the utility of this method, and highlight its potential role in the real-time simultaneous assessment of GLY and OXPHOS in vivo.
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