Moat chemotherapeutic drugs failed to effectively treat glioblastoma (GBM) on account of the existence of blood-brain barrier, which play a role in GBM. In this study, we constructed an integrated nanoprobe based on albumin nanoparticles for targeted diagnosis and treatment of GBM. The nanoprobe consists of albumin-coated superparamagnetic iron oxide, Carmustine and indocyanine green to achieve bimodal imaging and drug delivery. And the surface-coupled Angiopep-2 can specifically bind to LRP, which is overexpressed in BBB and GBM cells. This novel targeting imaging and drug delivery system provides an efficient strategy for targeted therapy and intraoperative localization of GBM.
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