Fluorine-19 MRI is a method that can utilize biocompatible perfluorocarbons to detect cancer. Implementation of a novel nanoemulsion has allowed for improved particle stability and PFC loading. Tumor-bearing mice were injected with perfluoro-[15-crown-5]-ether (PFCE) loaded nanoemulsion (NE) to explore the passive tumor targeting across 14 days. 19F MRI and subsequent ROI-image analysis suggested that there was a preferential retention of NE particles due to the enhanced permeability and retention (EPR) effect. This work demonstrates repeatable 19F imaging of a novel nanoemulsion that passively targets a fast growing tumor with improved stability and PFCE loading.