Abstract #3092

Investigation of a parallel transmission (pTx) GRE-readout with customized pulses for CEST MRI at 7 Tesla

Katharina Tkotz¹, Andrzej Liebert¹, Jürgen Herrler², Patrick Liebig³, Arnd Dörfler², Michael Uder¹, Moritz Zaiss^2,4, and Armin M. Nagel^1,5

¹Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, ²Department of Neuroradiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, ³Siemens Healthcare GmbH, Erlangen, Germany, ⁴Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ⁵Institute of Medical Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

In Chemical Exchange Saturation Transfer MRI B₁⁺-inhomogeneity influences both saturation and acquisition of the signal. Typically only a correction of the inhomogeneity of the CEST saturation is performed while the inhomogeneity of the readout is neglected. The influence of the readout was investigated in measurements using standard inhomogeneous 1Tx readout and a homogenized readout with customized pTx pulses. Compared to the 1Tx readout the readout with pTx pulses shows an increase of the homogeneity of the CEST contrast for CEST agents with low SNR like the amides and in regions with low 1Tx flip angle like the cerebellum.

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