Abstract #3108

Amide Proton Transfer imaging for differentiation of Tuberculomas from High-Grade Gliomas

Karthik Kulanthaivelu¹, Sanita Raju², Jitender Saini¹, Atchayaram Nalini², Nishanth Sadashiva³, Shashank Hegde⁴, Narayana Krishna Rolla⁵, and Indrajit Saha⁵

¹Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, India, ²Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India, ³Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, India, ⁴Philips Healthcare, Bengaluru, India, ⁵Philips Health Systems, Philips India Ltd, Bengaluru, India

Amide proton transfer imaging was investigated for its potential to discriminate tuberculomas from high-grade gliomas. The diagnosis was confirmed by histopathology, CSF examination or response to anti-tubercular therapy. The MTR_asym value of the Tuberculomas (mean 2.32± 0.50 s.d.) was significantly lower than high-grade gliomas (mean 4.32±0.84s.d.). Lower MTR_asym values in tuberculomas are suggestive of relatively reduced mobile amide protons compared to the tumoral microenvironment. Perilesional elevated APT values in tuberculomas are a unique observation and may reflect a milieu of inflammation.

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