Dynamic glucose-enhanced (DGE) images, detected by CEST, was used to provide direct information on glucose metabolism. It also provides the spatial distribution of the metabolic processes. The time-dependent glucose concentration variation in the striatum of HD shows that the glucose uptake in the HD mice striatum decreases with age. The groups of older than 9-11 weeks HD mice were easy to find the symptoms of HD, and their glucose uptaking also show a significant decrement. By contrast, WT mice show a mild decrease in the glucose uptake for the mice with similar age.