Abstract #3144

Distinguishing between macromolecular-driven magnetization transfer (MTSAT) and direct water saturation (MTDIR)

Dvir Radunsky¹, Tamar Blumenfeld-Katzir¹, and Noam Ben-Eliezer^1,2,3

¹Bio-medical Engineering, Tel Aviv University, Tel Aviv, Israel, ²Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, ³Center for Advanced Imaging Innovation and Research (CAI2R), New-York University Langone Medical Center, New York, NY, United States

Mapping of T₂ values is highly valuable for a wide range of applications. Still, accurate mapping is challenging due to the inherent bias of rapid Multi-Echo Spin-Echo (MESE) protocols by stimulated echoes, and also by magnetization transfer (MT). In this work, we investigate the different effects of macromolecular-driven MT (MT_SAT) and direct water saturation (MT_DIR) mechanisms on MESE signals, and their respective influence on T₂ values. The investigation includes quantitative MT measurements between protocols with different scan settings and protocol schemes, aiming to isolate the individual roles of MT_SAT and MT_DIR.

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