Abstract #3146

Towards understanding of CEST signal in breast cancer; relation between APT- MT- and B1 effects.

Elles Elschot¹, Lieke van den Wildenberg¹, Vitaly Khlebnikov¹, Dennis Klomp¹, and Jannie Wijnen¹

¹Radiology Department, UMC Utrecht, Utrecht, Netherlands

This study investigates the relation between B₁⁺ and signal amplitude of the APT and MT exchange pools in CEST MRI. We examined 19 breast cancer patients that underwent NAC treatment with CEST MRI at 7T. The data indicates evidence for an extra exchanging pool with strong B₁ dependence, that is more abundant in tumor tissue compared to healthy tissue. By identifying the exchanging components in this pool, a new biomarker for tumor tissue could be found and used to understand changes in response to NAC early during treatment.

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