B1 field deviations above and below 100% of the nominal prescribed values have been noted by previous authors as a potential source of error in MRI CPMG T2 relaxometry. We show in simulations of clinically realistic acquisition protocols that this effect causes fit instability and loss of precision, and corroborate this with in vivo lower limb muscle image data. We then introduce a B1 error polarity spatial regularization scheme, and show that this improves parameter estimation accuracy.
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