Phase-only Helmholtz-Electrical Property Tomography (PO-HEPT) has recently shown promise for the detection and grading of diffuse glioma. However, a brain glioma is usually located away from the centre of the brain where the transceive phase and phase-only approximations used in reconstruction may not be valid. Here we assessed the sensitivity of PO-HEPT in an anatomically realistic brain phantom where an off-centre glioma-compartment was incorporated, and using a clinically applicable MR sequence. Our results show that while the accuracy of the PO-HEPT deteriorates, its sensitivity is mostly unaffected, thus allowing correlative studies of tumour grading.
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