Abstract #3208

Use of high-resolution QSM to identify global patterns in the ex vivo human brain cortex at 7T

Leah Morgan¹, Berkin Bilgic¹, Andre van der Kouwe^1,2, Jean Augustinack^1,2, Jonathan Polimeni^2,3, Anna Blazejewska^1,2, Viviana Siless^1,2, Allison Stevens¹, Bram R Diamond¹, Natalya Slepneva¹, Bruce Fischl¹, and Divya Varadarajan¹

¹A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ²Harvard Medical School, Cambridge, MA, United States, ³Harvard-MIT Division of Health Sciences and Technology, Boston, MA, United States

Quantitative susceptibility mapping (QSM) can reflect the iron and myelin concentration within human brain tissue. Ex vivo MRI can allow us to study the cortical laminar structure at high-resolution. Here we conduct a study to combine the two, that is to analyze QSM maps of an ex vivo human brain cortex at 500um and 150um resolution. Our analysis shows matching global patterns of positive susceptibility at the gray-white boundary for both resolutions that were validated with iron-stain on a tissue-block. We find visual cortex, and localized regions of parietal and frontal lobe to contain the highest concentration of positive susceptibility.

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