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Abstract #3218

Liver iron content measurement in living mice with quantitative susceptibility mapping

Anton Abyzov1, Joao Piraquive1, Katell Peoc'h2, Philippe Garteiser1, and Bernard E. Van Beers1
1Laboratory of Imaging Biomarkers, Center of Research on Inflammation, UMR1149 Inserm-University Paris Diderot, Paris, France, 2Department of biochemistry, University Hospital Paris Nord - Beaujon, AP-HP, Clichy, France

To evaluate the feasibility of quantitative susceptibility mapping (QSM) in living mice liver and the robustness of QSM and transverse relaxation rate (R2*) based liver iron quantification. We show that QSM can be accurately performed in mice liver despite respiratory motion and that magnetic susceptibility measurements correlate more strongly with inductively coupled plasma mass spectrometry (ICP-MS) based iron quantification and have smaller standard deviations and narrower Bland-Altman agreement limits than R2* measurements.

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