Abstract #3227

A Novel Chemical Shift-Selective Fat Saturation RF Pulse Design with Robustness to B0/B1 Inhomogeneity: A Demonstration on Breast MRI at 3T

Feng Xu^1,2, Wenbo Li^1,2, Dapeng Liu^1,2, Dan Zhu³, Kelly Myers¹, Michael Shär¹, and Qin Qin^1,2

¹The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Biomedical Engineering, Johns Hopkins University, School of Medicine, Baltimore, MD, United States

Chemical shift-selective fat saturation (CHESS) is the most commonly used fat suppression technique for clinical MRI. Conventional Gaussian-shaped pulses are sensitive to B1 inhomogeneity and their wide transitional band can be affected by B0 off-resonance. Uniform fat saturation across a large field of view (FOV) is especially challenging for body and breast MRI at 3T. Here, we designed a novel frequency-selective RF pulse based on the optimal control theory with robustness to a targeted wide range of B0/B1 conditions. Its superior performance than the regular ones was demonstrated using T1-weighted sequences with whole-breast coverage.

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