Superparamagnetic Iron Oxide (SPIO) contrast agents are used extensively in molecular imaging studies as a tool to evaluate various SPIO-labelled cells. These studies would be greatly improved if multiple contrast agents could be quantified simultaneously. We combined an SSFP MR fingerprinting sequence with TE variation, and an extension of a concentration-dependent linear model, to achieve dual quantification and show viability of SPIO labelled CD8+ T cell mapping. As a pilot study for in vivo application, we demonstrate concentration mapping of a mouse injected with gadolinium, and R2* quantification of an SPIO labelled immune therapy injection site.
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