Abstract #3239

In Vivo Myelin Quantification by T1w/T2w: Its Relationship with Other MRI Quantifiers of Myelin and Specificity

Hiroyuki Hamaguchi¹, Nina Patzke², Yuta Urushibata³, Xinnan Li¹, Isabel Fernandez², and Khin Khin Tha^4,5

¹Department of Biomarker Imaging Science, Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo, Japan, ²Department of Biological Sciences, Faculty of Science, Hokkaido University, Sapporo, Japan, ³Siemens Healthineers, Tokyo, Japan, ⁴Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, ⁵Global Station for Quantum Medical Science and Engineering, Hokkaido University, Sapporo, Japan

The division of T1-weighted image by T2-weighted image (T1w/T2w) has recently been introduced as a myelin quantifier, which gained attention due to the ease of obtaining images. However, controversy exists about its performance. The aim of this study was to test the correlation of T1w/T2w with other MRI quantifiers of myelin, so as to determine its performance. Moderate to strong correlation of T1w/T2w with the other quantifiers was observed. T1w/T2w appears to be sensitive to detect an abnormality, but is not specific for myelin.

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