Higher sagittal sinus signal is present in the ASL images of patients with sickle cell disease (SCD). The purpose of this study was to assess if the signal in the sagittal sinus is correlated with clinical parameters and if this is affected by the vasoactive stimulus. The sagittal sinus signal was measured in patients with SCD and in healthy controls. Signal in sagittal sinus of the SCD patients were significantly correlated with clinical parameters including hemolysis markers. Our results show that sagittal sinus signal can be used as a hemodynamic proxy parameter in patients with SCD.