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Abstract #3282

Optimal subject-specific pCASL settings by automated inner-scan timing adaption

Nora-Josefin Breutigam1, Daniel Christopher Hoinkiss1, Mareike Alicja Buck1, Amnah Mahroo1, Federico von Samson-Himmelstjerna1, and Matthias G√ľnther1,2
1MR Physics, Fraunhofer MEVIS, Bremen, Germany, 2MR-Imaging and Spectroscopy, Faculty 01 (Physics/Electrical Engineering, University of Bremen, Bremen, Germany

The presented automated inner-scan timing adjustment for subject-specific pCASL measurements can reduce uncertainties in perfusion quantification. The high variability of arterial transit times often leads to undesired arterial transit delay (ATD) artifacts. The method evaluated here allows the optimal FL-bolus duration to be individually adjusted by analyzing intermediate decoded perfusion-weighted images and directly adjusting the sub-bolus durations without increasing the measurement time. The aim is to reduce the FL-bolus duration as much as necessary, but to keep it as long as possible in order to obtain a maximum signal.

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