Abstract #3301

Improving Robustness to Field Imperfections for Velocity-Selective Inversion prepared Arterial Spin Labeling through Dynamic Phase-Cycling

Dapeng Liu^1,2, Wenbo Li^1,2, Feng Xu^1,2, Dan Zhu³, Taehoon Shin^4,5, and Qin Qin^1,2

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Division of Mechanical and Biomedical Engineering, Ewha Womans University, Seoul, Korea, Republic of, ⁵Department of Medicine, Case Western Reserve University, Cleveland, OH, United States

In Fourier-transform based velocity-selective inversion (FT-VSI) arterial spin labeling (ASL), either velocity-insensitive or velocity-compensated waveforms could be applied for control modules. Under poor B0/B1 conditions with inefficient refocusing, the scheme with velocity-insensitive control is susceptible to strong false signal but maintained high labeling efficiency, while the scheme with velocity-compensated control has poor velocity-selective labeling profiles. This study overcome these problems by proposing a dynamic phase-cycling scheme based on velocity-insensitive waveform and improve the robustness to B0/B1 field inhomogeneities for VSI ASL. Simulation, phantom and brain ASL scans were conducted for demonstration.

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