In acute ischemic stroke due to large vessel occlusion (LVO), variability of infarct evolution observed in humans is closely captured by the canine LVO model, which can predict dogs to be slow or fast evolvers. The extent of collateral blood supply has shown good correlations with infarct growth rate. This study investigated the use of intravoxel incoherent motion (IVIM) MRI to quantify microvascular perfusion. Longitudinal IVIM parameters clearly differentiated between slow and fast evolvers depicting collateral blood flow changes, which can determine the severity of ischemic injury and also track longitudinal changes in response to therapeutic treatments/interventions in preclinical studies.
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