Abstract #3318

Parametric maps of murine cancers from dynamic contrast enhanced MRI: low versus high doses of contrast agent

Xiaobing Fan¹, Xueyan Zhou², Devkumar Mustafi¹, Federico Pineda¹, Erica Markiewicz¹, Marta Zamora¹, Deepa Sheth¹, Olufunmilayo I. Olopade³, and Gregory S. Karczmar¹

¹Radiology, The University of Chicago, Chicago, IL, United States, ²School of Technology, Harbin University, Harbin, China, ³Medicine, The University of Chicago, Chicago, IL, United States

We compared dynamic contrast enhanced (DCE) MRI with low (0.04mmol/kg) and high doses (0.2mmol/kg) of contrast agent on C3H mice at 9.4T with 1.5s temporal resolution before and after a bolus injection. The standard Tofts model was used to extract physiological parameters (K^trans and v_e) with arterial input function derived from muscle reference tissue. On average, rate constants were larger for low dose than high dose data. There were strong correlations for K^trans and v_e between low and high dose data. Therefore, low dose may be as effective as a high dose of contrast agent for cancer diagnosis.

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