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Abstract #3333

High-resolution multifrequency MR Elastography of liver tumors using a compact tabletop MRI Scanner

Mehrgan Shahryari1, Gergely Bertalan1, Helge Herthum1, Heiko Tzsch├Ątzsch1, J├╝rgen Braun2, Marcus R. Makowski1, Sarah Keller1, and Ingolf Sack1
1Department of Radiology, Berlin, Germany, 2Institute of Medical Informatics, Berlin, Germany

MR elastography is a clinical imaging technique for the mapping of viscoelastic tissue properties on the millimeter scale. However, basic studies in tissue samples require a compact MRE setup which provides sub-millimeter resolution. We here introduce compact 0.5-Tesla tabletop multifrequency MRE for high-resolution mapping of viscoelasticity and water diffusion in VX2-liver tumors and surrounding liver tissue. Ex-vivo tumors were stiffer, more viscous and showed higher water diffusivity than adjacent tissue. In tumors, viscosity was inversely correlated with water diffusion while in liver tissue, stiffness was inversely correlated with diffusion.

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