Motion-induced artifacts in quantitative MRI may not be visually detectable. MRF has shown to be robust to in-plane movement, and methods to mitigate it were made available. However, the impact of clinically prevalent motion patterns has not yet been investigated. The effect of realistic motion data from patients with neurodegenerative disorders and young/elderly controls on 2D FISP-MRF is therefore investigated in this simulation study. Results are validated with in-vivo motion-tracked measurements. Although through-plane motions were shown to significantly impact MRF parametric maps (particularly T2), MRF may preserve its sensitivity in clinical cases in which expected lesion-related differences are large enough.