Abstract #3381

Filter-pipeline based algorithm to find the AIF in DCE-MRI images for perfusion calculation of rectal cancer.

Christian Tönnes¹, Sonja Janssen², Alena-Kathrin Schnurr¹, Tanja Uhrig¹, Khanlian Chung¹, Lothar R. Schad¹, and Frank Gerrit Zöllner¹

¹Computer Assisted Clinical Medicine, Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Perfusion calculation is highly dependent on the expertise and input of the physician and therefore reproduction of the results is difficult. A filter pipeline based algorithm for selecting the AIF ROI was implemented and evaluated. Our results show that such an algorithm can be used to determine the AIF ROI for perfusion calculation in dynamic contrast enhanced MRI images with a high accuracy. A fully automatic and deterministic algorithm removes the need for manual interaction and standardizes clinical perfusion measurements while simultaneously reducing the time requirement for the ROI determination by 86%.

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