Abstract #3468

Direct Estimation of pre-contrast T1 for DCE-MRI

Zhibo Zhu¹, Yannick Bliesener¹, R. Marc Lebel^2,3, and Krishna Shrinivas Nayak¹

¹Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, ²Global MR Applications & Workflow, GE Healthcare, Calgary, AB, Canada, ³Radiology, University of Calgary, Calgary, AB, Canada

Quantitative DCE-MRI requires pre-contrast T₁ mapping with matching resolution and coverage. Recent studies have shown that sparse sampling and constrained reconstruction can be applied to both DCE-MRI and pre-contrast T₁ mapping with the variable flip angle (VFA) approach. Here, we demonstrate and evaluate direct estimation of T1 from sparsely sampled VFA raw data. In healthy subjects, we demonstrate superior T₁ estimation compared with prior methods at subsampling factors >10.

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