Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by focal inflammatory demyelination. In chronic active lesions, microglia and macrophages may contain high amounts of iron and express markers of pro-inflammatory polarization, driving tissue damage and disease progression. Therefore, studying the mechanisms behind iron accumulation and microglial inflammation are of great clinical importance, but require rigorous histological characterization of autopsied brain tissue from MS patients. We developed a rapid, automated method to quantify histopathological markers in human tissue and then validated our findings with manual counting and quantitative susceptibility mapping (QSM).
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