In this work we show the first experimental images, in both phantoms and humans, from 3D Cartesian Fast Rotary Nonlinear Spatial Acquisition (FRONSAC) imaging. FRONSAC adds oscillating nonlinear gradients to a standard Cartesian sequence, such as 3D GRE or MP-RAGE, both of which were acquired for this work. The additional modulation reduces undersampling artifacts and improves response to advanced reconstruction techniques, while maintaining other desirable image characteristics. In addition, we show that a PSF-based reconstruction, a generalization of the approach used in wave imaging, can be applied to FRONSAC data, yielding faster reconstructions that can be highly parallelized.
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