We propose a method that is a Combined Approach of Variable Flip Angle (VFA), Keyhole undersampling and Averaging (CAVKA). It is designed to optimize the use of the limited magnetization and to accelerate the acquisition in MRI series that suffer from low SNR and thus require averaging. The method is applied to the acquisition of a CEST (chemical exchange saturation transfer) image series, where the sensed nucleus is hyperpolarized 129Xe. There it provides ~4-fold SNR increase compared to conventional imaging without averaging or 7-fold acceleration with the same SNR compared to imaging with averaging.
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